I use no programs for adjusting ui, all of the changes I do are done using windows 10 and ui options.
I am a programmer so I use my computer a lot. I disagree about icons on the desktop. The desktop represents your workspace. For me it fills up as I work on a project, and when I am done or it gets cluttered, I file it away. Win+d gets to and from the desktop, so all of the files are one press away at any point. I keep it free of shortcuts.
I should also mention most of my work is done on laptops, which is not what I prefer, but they are just too useful. Since I don't have 2 monitors, I often work from windows I dock using win+arrow or dragging the header to one of the screen corners. I also map the 4 finger vertical swipe to volume control.
For selecting programs I just do winkey then type the first couple of letters, I like not having to take my hands off of the keyboard.
I am not an organized person irl, but I've found my layout helps me stay sane. There are thing I would like to change though. I think with OLEDs on the way, dark interfaces should support blacker blacks instead of these dim greys. I also would like to see a way to have ui elements + lines move ever so slightly every hour to help against burn-in.