Exploits of the game to cause chaos, two main events came to mind.
The first was the ultima online slime incident.
Ultima online slimes had a chance to split into two separate enemies when hit with a weapon, a particular player decided to fill his entire in game house with slimes (considering the sheer volume it must have taken days), when he opened the front door the slimes exploded out of the door due to clipping and caused the server to crash in the process killing all the players logged in.
Later he returned with a refined method, using weak AoE attacks he began to fill another house and requested the players pay him a large sum, the ransom went unpaid and he crashed the server again.
After a couple of copycat crashers the developers had to step in and remove the splitting mechanic all together.
The other event is fairly well known, the falador massacre in runescape
Runescape is a fairly friendly MMO with very restrictive PvP combat, after an update that allowed dueling to take place in a separate instance from the normal world one player found he could PvP in the normal world. Massacring players and stealing alot of in-game currency.