I don't really read webcomics to be honest, but I might check out those.
Oh cool.
I guess I should explain what they are first...
Homestuck - A story set up in the form of a text adventure game (but with pictures... And flash animations w/ music) about 4 kids who play a game that has some huge consequences. Be warned, this thing is like 3000+ pages long already (it's only started 2 years ago) and updates like 5 pages a day. Plus it's one of the more confusing stories out there. This isn't like one of those comics that updates like maybe once a month. This is quite the opposite. This is also my favorite in the list.
The Adventures of Dr. McNinja - A comic book style comic about an Irish ninja doctor and his 12 year old mexican gunslinger sidekick named Gordito who grew a mustache out of sheer force of will and rides a velociraptor named Yoshi. While it may sound ridiculous (and it certainly is) it actually has a really good story, excellent characters, and hilarious moments. This isn't just lol random awesome things happening for no reason like Axe Cop, this is an actually structured story that is simultaneously ridiculously awesome. A HUGE recommend.
XKCD - Pretty well known. Stick figure comic about science. Not AMAZING, but certainly amusing. About as nerdy as it gets. It's certainly not everyone's cup of tea, though. Especially if you're not a computer person...
Brawl in the Family - A gag comic that updates twice a week about the characters in Super Smash Bros. Brawl. Most early jokes revolve around Kirby eating silly things and him changing into humourous forms. After that, though, it certainly has some clever humour, and a certain charm if you're a Nintendo gamer.
Dinosaur Comics - A rather strange comic that has the same 6 panels everyday, just with different text. Not nearly as bad as it sounds. Mostly about complex philosophical arguments brought down to hilariously simple levels. Not an archive binge-worthy comic, to be sure, but a nice thing to look at every day. Again, not for everyone.
F@NB0Y$ - A gamers on a couch comic done right. Has humourous characterization mocking the 3 main types of console fanboys (well, one is a girl) and fairly interesting stories. Two of the side characters are a PC gamer and a table top gamer, but they don't show up too often. Not the best on this list, admittedly, but again, it has it's own little charm. Also, it's not exactly updating much anymore, maybe only once or twice a year at most. Worthy of a look at, at least...
Concerned - One of the best Gmod comics I've seen. Follows the adventures of one Gordon Frohman (That's FROHMAN!) as he bumbles his way through the half life 2 universe. Has a lot of humourous lampshade hanging of the series, as well as a generaly goofy sense of humour. If you've sworn off Gmod comics for good, then you might not like this, but it's certainly fairly well done, and uses the Gmod tools very well. Already finished.