I tried 1nsane, I've included both screenshots.
The menu doesn't scale, you need to go in game to see it. And even then, you might have to zoom in to 400% or so to see the actual difference on my screenshots. (2k native vs 4k downscaled to 2k).
Lutris settings:
With gamescope you're only defining a virtual screen space for the game to render in. It's down to the game/dgvoodoo to be able to render at the higher resolution that gamescope is telling the game is available.
Native 2K
4K Downscaled
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For GLXGears you also need to tell it to render in fullscreen so it uses all the available resolution that gamescope is allowing it to.
gamescope -w 7680 -h 4320 -W 3840 -H 2160 -- glxgears -fullscreen