I took the plunge and decided to start using D-Fend Reloaded this past Saturday, which turned out well....for the most part. I can't even say that getting games to work has been trial and error; the fact that there are default profiles for various eras of DOS titles made it a lot easier than I thought to get most of the games I have up and running. Unfortunately, there are still four or five games I have problems with, one of which has a pre-installed profile in D-Fend Reloaded; the titles in question simply don't start after being configured, and I've listed them in the re-edited text file below.
Games that I need help with to get running in D-Fend Reloaded.txt