Nice graphics, interesting story, neat worldbuilding, good attention to detail, and mindblowingly obnoxious controls.
I would describe the gameplay as "Super Meat Boy on Xen with noodle arms". The level design is just bad, as not only simply getting around is a tedious chore but it's also a "where the fuck do I go" kind of game where your destination is never clear and you do a lot of going in circles accidentally. The experience reminded me a lot of Getting Over It with Bennet Foddy, except in that game the horrible controls were the point. Here, they just get in the way. I don't even want to know the end of the story because of how frustrating the whole thing is. And if you think I just hate difficulty: not at all, Dark Souls is one of my favourite games of all time. But A Story About My Uncle isn't just challenging; it made me feel like I was repeatedly trying to put a thread into the hole of a sewing needle while covered in oil and blind drunk.
This game made me hate grappling hooks.